› 2mzz

Solution NMR

NMR structure of APOBEC3G NTD variant, sNTD

Released:
DOI: 10.2210/pdb2mzz/pdb
PDB entry 2mzz coloured by chain, ensemble of 10 models, front view.
PDB entry 2mzz coloured by chain, ensemble of 10 models, side view.
PDB entry 2mzz coloured by chain, ensemble of 10 models, top view.
Source organism: synthetic construct
Primary publication:
Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G.
Kouno T, Luengas EM, Shigematsu M, Shandilya SM, Zhang J, Chen L, Hara M, Schiffer CA, Harris RS, Matsuo H
Nat Struct Mol Biol 22 485-91 (2015)
PMID: 25984970

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G variant Chain: A
Molecule details ›
Chain: A
Length: 180 amino acids
Theoretical weight: 21.32 KDa
Source organism: synthetic construct
Expression system: Escherichia coli

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 30%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

11 review citations

APOBEC3G-Mediated G-to-A Hypermutation of the HIV-1 Genome: The Missing Link in Antiviral Molecular Mechanisms.
Okada et al. (2016)
10 more

14 mentions without citation

The APOBEC Protein Family: United by Structure, Divergent in Function.
Salter et al. (2016)
13 more