2mpm

Solution NMR

Structural Basis of Receptor Sulfotyrosine Recognition by a CC Chemokine: the N-terminal Region of CCR3 Bound to CCL11/Eotaxin-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Eotaxin Chain: A
Molecule details ›
Chain: A
Length: 74 amino acids
Theoretical weight: 8.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51671 (Residues: 24-97; Coverage: 100%)
Gene names: CCL11, SCYA11
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
CCR3 Chain: B
Molecule details ›
Chain: B
Length: 16 amino acids
Theoretical weight: 1.94 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: torsion angle dynamics
Chemical shifts: BMR19989  
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided