› 2mmg

Solution NMR

Structural Characterization of the Mengovirus Leader Protein Bound to Ran GTPase by Nuclear Magnetic Resonance

Released:
DOI: 10.2210/pdb2mmg/pdb
PDB entry 2mmg coloured by chain, ensemble of 10 models, front view.
PDB entry 2mmg coloured by chain, ensemble of 10 models, side view.
PDB entry 2mmg coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase.
Bacot-Davis VR, Ciomperlik JJ, Basta HA, Cornilescu CC, Palmenberg AC
Proc Natl Acad Sci U S A 111 15792-7 (2014)
PMID: 25331866

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158719 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTP-binding nuclear protein Ran Chain: A
Molecule details ›
Chain: A
Length: 216 amino acids
Theoretical weight: 24.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P62826 (Residues: 1-216; Coverage: 100%)
Gene names: ARA24, OK/SW-cl.81, RAN
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

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Citations

2 review citations

Nucleocytoplasmic Trafficking Perturbation Induced by Picornaviruses.
Lizcano-Perret et al. (2021)
1 more

1 mention without citation

Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase.
Bacot-Davis et al. (2014)