Solution NMR

NMR structure of the basic helix-loop-helix region of the transcriptional repressor HES-1


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Transcription factor HES-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 70 amino acids
Theoretical weight: 8.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q14469 (Residues: 27-95; Coverage: 25%)
Gene names: BHLHB39, HES1, HL, HRY
Sequence domains: Helix-loop-helix DNA-binding domain
Structure domains: Helix-loop-helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 40%
Refinement method: restrained molecular dynamics
Chemical shifts: BMR19614  
Expression system: Escherichia coli