2mda

Solution NMR

The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase

Released:

Function and Biology Details

Reaction catalysed:
L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine 3-monooxygenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 95 amino acids
Theoretical weight: 10.49 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P04177 (Residues: 65-159; Coverage: 19%)
Gene name: Th
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 41%
Refinement method: simulated annealing
Chemical shifts: BMR19482  
Expression system: Escherichia coli