2m49

Solution NMR

Structural Insights into Human S100B and Basic Fibroblast Growth Factor (FGF2) Interaction

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor 2 Chains: A, C
Molecule details ›
Chains: A, C
Length: 126 amino acids
Theoretical weight: 14.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09038 (Residues: 161-286; Coverage: 44%)
Gene names: FGF2, FGFB
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Protein S100-B Chains: B, D
Molecule details ›
Chains: B, D
Length: 91 amino acids
Theoretical weight: 10.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04271 (Residues: 2-92; Coverage: 99%)
Gene name: S100B
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 8%
Refinement method: simulated annealing
Chemical shifts: BMR18995  
Expression system: Escherichia coli BL21(DE3)