Solution NMR

Identification and structural basis for a novel interaction between Vav2 and Arap3

Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Guanine nucleotide exchange factor VAV2 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 14.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P52735 (Residues: 659-771; Coverage: 13%)
Gene name: VAV2
Sequence domains: SH2 domain
Structure domains: SH2 domain
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.13 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q8WWN8 (Residues: 1404-1412; Coverage: 1%)
Gene names: ARAP3, CENTD3

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: simulated annealing
Chemical shifts: BMR18182  
Expression systems:
  • Escherichia coli
  • Not provided