PDBe 2lea

Solution NMR

Solution structure of human SRSF2 (SC35) RRM


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Serine/arginine-rich splicing factor 2 Chain: A
Molecule details ›
Chain: A
Length: 135 amino acids
Theoretical weight: 15.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q01130 (Residues: 1-101; Coverage: 46%)
Gene names: SFRS2, SRSF2
Sequence domains: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: simulated annealing
Chemical shifts: BMR17705  
Expression system: Escherichia coli BL21(DE3)