Solution NMR

Spatial structure of dimeric ErbB3 transmembrane domain


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Receptor tyrosine-protein kinase erbB-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 40 amino acids
Theoretical weight: 4.7 KDa
Source organism: Homo sapiens
Expression system: cell-free synthesis
  • Canonical: P21860 (Residues: 639-670; Coverage: 2%)
  • Best match: P21860-5 (Residues: 1-27)
Gene names: ERBB3, HER3
Structure domains: cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 31%
Refinement method: simulated annealing
Chemical shifts: BMR17488  
Expression system: cell-free synthesis