› 2l98

Solution NMR

Structure of trans-Resveratrol in complex with the cardiac regulatory protein Troponin C

Released:
DOI: 10.2210/pdb2l98/pdb
PDB entry 2l98 coloured by chain, ensemble of 20 models, front view.
PDB entry 2l98 coloured by chain, ensemble of 20 models, side view.
PDB entry 2l98 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of trans-resveratrol in complex with the cardiac regulatory protein troponin C.
Pineda-Sanabria SE, Robertson IM, Sykes BD
Biochemistry 50 1309-20 (2011)
PMID: 21226534

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159088 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: A
Molecule details ›
Chain: A
Length: 72 amino acids
Theoretical weight: 8.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P63316 (Residues: 91-161; Coverage: 44%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand STL 1 x STL
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: water refinement
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Evolutionary Limitation and Opportunities for Developing tRNA Synthetase Inhibitors with 5-Binding-Mode Classification.
Fang et al. (2015)
5 more

5 mentions without citation

Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs.
Li et al. (2015)
4 more