PDBe 2l35

Solution NMR

Structure of the DAP12-NKG2C transmembrane heterotrimer

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NKG2-C type II integral membrane protein; TYRO protein tyrosine kinase-binding protein Chain: A
Molecule details ›
Chain: A
Length: 63 amino acids
Theoretical weight: 6.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26717 (Residues: 72-100; Coverage: 13%)
  • Canonical: O43914 (Residues: 35-67; Coverage: 36%)
  • nullnull
Gene names: DAP12, KARAP, KLRC2, NKG2C, TYROBP
Structure domains: YojJ-like
TYRO protein tyrosine kinase-binding protein Chain: B
Molecule details ›
Chain: B
Length: 32 amino acids
Theoretical weight: 3.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43914 (Residues: 35-66; Coverage: 35%)
Gene names: DAP12, KARAP, TYROBP

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli