Solution NMR

Structure of CBP nuclear coactivator binding domain in complex with p53 TAD


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone lysine acetyltransferase CREBBP Chain: A
Molecule details ›
Chain: A
Length: 59 amino acids
Theoretical weight: 6.57 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P45481 (Residues: 2059-2117; Coverage: 2%)
Gene names: Cbp, Crebbp
Structure domains: Nuclear receptor coactivator, CREB-bp-like, interlocking domain
Cellular tumor antigen p53 Chain: B
Molecule details ›
Chain: B
Length: 49 amino acids
Theoretical weight: 5.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P04637 (Residues: 13-61; Coverage: 13%)
Gene names: P53, TP53
Sequence domains: Transactivation domain 2
Structure domains: Insulin-like, subunit E

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 93%
Refinement method: simulated annealing, molecular dynamics
Chemical shifts: BMR17073  
Expression system: Escherichia coli