› 2kyx

Solution NMR

Solution structure of the RRM domain of CYP33

Released:
DOI: 10.2210/pdb2kyx/pdb
PDB entry 2kyx coloured by chain, ensemble of 10 models, front view.
PDB entry 2kyx coloured by chain, ensemble of 10 models, side view.
PDB entry 2kyx coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
The PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .
Park S, Osmers U, Raman G, Schwantes RH, Diaz MO, Bushweller JH
Biochemistry 49 6576-86 (2010)
PMID: 20677832

Function and Biology Details

Reaction catalysed: 
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194001 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-prolyl cis-trans isomerase E Chain: A
Molecule details ›
Chain: A
Length: 83 amino acids
Theoretical weight: 9.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UNP9 (Residues: 3-83; Coverage: 27%)
Gene names: CYP33, PPIE
Sequence domains: RNA recognition motif
Structure domains: Alpha-Beta Plaits

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

20 review citations

ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.
Long et al. (2013)
19 more

5 mentions without citation

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression.
Thapar R. (2015)
4 more