› 2klq

Solution NMR

The solution structure of CBD of human MCM6

Released:
DOI: 10.2210/pdb2klq/pdb
PDB entry 2klq coloured by chain, ensemble of 20 models, front view.
PDB entry 2klq coloured by chain, ensemble of 20 models, side view.
PDB entry 2klq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
Wei Z, Liu C, Wu X, Xu N, Zhou B, Liang C, Zhu G
J Biol Chem 285 12469-73 (2010)
PMID: 20202939

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172036 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA replication licensing factor MCM6 Chain: A
Molecule details ›
Chain: A
Length: 114 amino acids
Theoretical weight: 13.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14566 (Residues: 708-821; Coverage: 14%)
Gene name: MCM6
Sequence domains: MCM6 C-terminal winged-helix domain
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

12 review citations

Mechanisms for initiating cellular DNA replication.
Costa et al. (2013)
11 more

6 mentions without citation

Mechanisms and regulation of DNA replication initiation in eukaryotes.
Parker et al. (2017)
5 more