› 2kg7

Solution NMR

Structure and features of the complex formed by the tuberculosis virulence factors Rv0287 and Rv0288

Released:
DOI: 10.2210/pdb2kg7/pdb
PDB entry 2kg7 coloured by chain, ensemble of 30 models, front view.
PDB entry 2kg7 coloured by chain, ensemble of 30 models, side view.
PDB entry 2kg7 coloured by chain, ensemble of 30 models, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Solution structure of the M. tuberculosis EsxG-EsxH complex: functional implications and comparisons with other M. tuberculosis Esx family complexes
Ilghari D, Lightbody KL, Veverka V, Waters LC, Muskett FW, Renshaw PS, Carr M
J. Biol. Chem. (2011)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129467 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
ESAT-6-like protein EsxG Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 9.79 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: O53692 (Residues: 1-97; Coverage: 100%)
Gene names: Rv0287, esxG
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6-like
ESAT-6-like protein EsxH Chain: B
Molecule details ›
Chain: B
Length: 97 amino acids
Theoretical weight: 10.48 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WNK3 (Residues: 1-96; Coverage: 100%)
Gene names: MTV035.16, Rv0288, cfp7, esxH
Sequence domains: Proteins of 100 residues with WXG
Structure domains: ESAT-6-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

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