2kfx

Solution NMR

Structure of the N-terminal domain of human cardiac troponin C bound to calcium ion and to the inhibitor W7

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C.
OpenAccess logo Biochemistry 48 5541-52 (2009)
PMID: 19419198

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, slow skeletal and cardiac muscles Chain: T
Molecule details ›
Chain: T
Length: 89 amino acids
Theoretical weight: 10.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63316 (Residues: 1-89; Coverage: 55%)
Gene names: TNNC, TNNC1
Sequence domains: EF-hand domain pair

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 4%
Refinement method: molecular dynamics
Chemical shifts: BMR16190  
Expression system: Escherichia coli