› 2k2m

Solution NMR

Structural Basis of PxxDY Motif Recognition in SH3 Binding

Released:
DOI: 10.2210/pdb2k2m/pdb
PDB entry 2k2m coloured by chain, ensemble of 20 models, front view.
PDB entry 2k2m coloured by chain, ensemble of 20 models, side view.
PDB entry 2k2m coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of PxxDY motif recognition in SH3 binding.
Aitio O, Hellman M, Kesti T, Kleino I, Samuilova O, Pääkkönen K, Tossavainen H, Saksela K, Permi P
J Mol Biol 382 167-78 (2008)
PMID: 18644376

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186233 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor kinase substrate 8-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8TE68 (Residues: 481-536; Coverage: 8%)
Gene names: DRC3, EPS8L1, EPS8R1, PP10566
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

5 review citations

SH3 domain ligand binding: What's the consensus and where's the specificity?
Saksela et al. (2012)
4 more

2 mentions without citation

From Binding-Induced Dynamic Effects in SH3 Structures to Evolutionary Conserved Sectors.
Zafra Ruano et al. (2016)
1 more