› 2jzq

Solution NMR

Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures

Released:
DOI: 10.2210/pdb2jzq/pdb
PDB entry 2jzq coloured by chain, ensemble of 20 models, front view.
PDB entry 2jzq coloured by chain, ensemble of 20 models, side view.
PDB entry 2jzq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
Hua QX, Nakagawa SH, Jia W, Huang K, Phillips NB, Hu SQ, Weiss MA
J Biol Chem 283 14703-16 (2008)
PMID: 18332129

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134181 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin B chain Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54, 90-110; Coverage: 59%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family
Structure domains: Insulin-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, SIMULATED ANNEALING
Expression system: Not provided

Quick links

Citations

7 review citations

Frustration in biomolecules.
Ferreiro et al. (2014)
6 more

5 mentions without citation

Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
Hua et al. (2008)
4 more