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Solution NMR

NMR structure of the ARID domain from the histone H3K4 demethylase RBP2

Released:
Source organism: Homo sapiens
Primary publication:
The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC motif.
Nat. Struct. Mol. Biol. 15 419-21 (2008)
PMID: 18270511

Function and Biology Details

Reaction catalysed:
(1a) a [histone H3]-N(6),N(6),N(6)-trimethyl-L-lysine(4) + 2-oxoglutarate + O(2) = a [histone H3]-N(6),N(6)-dimethyl-L-lysine(4) + succinate + formaldehyde + CO(2)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific demethylase 5A Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P29375 (Residues: 85-175; Coverage: 5%)
Gene names: JARID1A, KDM5A, RBBP2, RBP2
Sequence domains: ARID/BRIGHT DNA binding domain
Structure domains: ARID DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21