› 2jm5

Solution NMR

Solution Structure of the RGS domain from human RGS18

Released:
DOI: 10.2210/pdb2jm5/pdb
PDB entry 2jm5 coloured by chain, ensemble of 20 models, front view.
PDB entry 2jm5 coloured by chain, ensemble of 20 models, side view.
PDB entry 2jm5 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundström M, Doyle DA, Siderovski DP
Proc Natl Acad Sci U S A 105 6457-62 (2008)
PMID: 18434541

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Regulator of G-protein signaling 18 Chain: A
Molecule details ›
Chain: A
Length: 151 amino acids
Theoretical weight: 17.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NS28 (Residues: 75-223; Coverage: 63%)
Gene names: RGS13, RGS18
Sequence domains: Regulator of G protein signaling domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli

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Citations

23 review citations

Update on melatonin receptors: IUPHAR Review 20.
Jockers et al. (2016)
22 more

1 mention without citation

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Soundararajan et al. (2008)