› 2jgw

Solution NMR

Structure of CCP module 7 of complement factor H - The AMD at risk varient (402H)

Released:
DOI: 10.2210/pdb2jgw/pdb
PDB entry 2jgw coloured by chain, ensemble of 20 models, front view.
PDB entry 2jgw coloured by chain, ensemble of 20 models, side view.
PDB entry 2jgw coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.
Herbert AP, Deakin JA, Schmidt CQ, Blaum BS, Egan C, Ferreira VP, Pangburn MK, Lyon M, Uhrín D, Barlow PN
J Biol Chem 282 18960-8 (2007)
PMID: 17360715

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H Chain: A
Molecule details ›
Chain: A
Length: 61 amino acids
Theoretical weight: 6.99 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08603 (Residues: 386-446; Coverage: 5%)
Gene names: CFH, HF, HF1, HF2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: ARIA 2.0
Expression system: Komagataella pastoris

Quick links

Citations

32 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
31 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)