2j6l

X-ray diffraction
1.3Å resolution

Structure of aminoadipate-semialdehyde dehydrogenase

Released:

Function and Biology Details

Reactions catalysed:
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O (spontaneous)
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-aminoadipic semialdehyde dehydrogenase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 500 amino acids
Theoretical weight: 54.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P49419 (Residues: 29-527; Coverage: 93%)
Gene names: ALDH7A1, ATQ1
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments


Cofactor: Ligand NAI 8 x NAI
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 155.289Å b: 162.326Å c: 159.016Å
α: 90° β: 94.17° γ: 90°
R-values:
R R work R free
0.14 0.137 0.189
Expression system: Escherichia coli BL21(DE3)