2iyv

X-ray diffraction
1.35Å resolution

Shikimate kinase from Mycobacterium tuberculosis in complex with ADP, open LID (conf. B)

Released:

Function and Biology Details

Reaction catalysed:
ATP + shikimate = ADP + shikimate 3-phosphate
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Shikimate kinase Chain: A
Molecule details ›
Chain: A
Length: 184 amino acids
Theoretical weight: 19.68 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WPY3 (Residues: 1-176; Coverage: 100%)
Gene names: MTCY159.17, Rv2539c, aroK
Sequence domains: Shikimate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P21
Unit cell:
a: 38.618Å b: 44.193Å c: 51.289Å
α: 90° β: 109.13° γ: 90°
R-values:
R R work R free
0.14 0.138 0.178
Expression system: Escherichia coli