PDBe 2iyb

X-ray diffraction
2.35Å resolution

Structure of complex between the 3rd LIM domain of TES and the EVH1 domain of Mena

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein enabled homolog Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 114 amino acids
Theoretical weight: 12.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8N8S7 (Residues: 1-113; Coverage: 19%)
Gene names: ENAH, MENA
Sequence domains: WH1 domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Testin Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 65 amino acids
Theoretical weight: 7.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UGI8 (Residues: 357-421; Coverage: 15%)
Gene name: TES
Structure domains: Cysteine Rich Protein

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21212
Unit cell:
a: 66.548Å b: 292.927Å c: 37.126Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.199 0.259
Expression system: Escherichia coli