2iwl

X-ray diffraction
2.6Å resolution

Structure of the PX Domain of Phosphoinositide 3-Kinase-C2alpha

Released:

Function and Biology Details

Reaction catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha Chain: X
Molecule details ›
Chain: X
Length: 140 amino acids
Theoretical weight: 16.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O00443 (Residues: 1405-1544; Coverage: 8%)
Gene name: PIK3C2A
Sequence domains: PX domain
Structure domains: Phox-like domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P432
Unit cell:
a: 115.933Å b: 115.933Å c: 115.933Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.247 0.29
Expression system: Escherichia coli BL21(DE3)