2ice

X-ray diffraction
3.1Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Complement C3 beta chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 642 amino acids
Theoretical weight: 71.17 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 23-664; Coverage: 39%)
Gene names: C3, CPAMD1
Sequence domains:
Structure domains:
Complement C3c alpha' chain fragment 1 Chains: B, E
Molecule details ›
Chains: B, E
Length: 206 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 749-954; Coverage: 13%)
Gene names: C3, CPAMD1
Sequence domains: Alpha-2-macroglobulin family
Structure domains:
Complement C3c alpha' chain fragment 2 Chains: C, F
Molecule details ›
Chains: C, F
Length: 343 amino acids
Theoretical weight: 39.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P01024 (Residues: 1321-1663; Coverage: 21%)
Gene names: C3, CPAMD1
Sequence domains:
Structure domains:
V-set and immunoglobulin domain-containing protein 4 Chains: S, T
Molecule details ›
Chains: S, T
Length: 119 amino acids
Theoretical weight: 13.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y279 (Residues: 19-137; Coverage: 31%)
Gene names: CRIg, UNQ317/PRO362, VSIG4, Z39IG
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: C2
Unit cell:
a: 384.936Å b: 65.213Å c: 147.676Å
α: 90° β: 102.91° γ: 90°
R-values:
R R work R free
0.239 0.236 0.295
Expression system: Escherichia coli