X-ray diffraction
2.7Å resolution

Crystal Structure of Human Cysteine Dioxygenase in Complex with Substrate Cysteine


Function and Biology Details

Reaction catalysed:
L-cysteine + O(2) = 3-sulfinoalanine
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Cysteine dioxygenase type 1 Chain: A
Molecule details ›
Chain: A
Length: 205 amino acids
Theoretical weight: 23.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q16878 (Residues: 1-200; Coverage: 100%)
Gene name: CDO1
Sequence domains: Cysteine dioxygenase type I
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P65
Unit cell:
a: 131.1Å b: 131.1Å c: 34.3Å
α: 90° β: 90° γ: 120°
R R work R free
0.182 0.178 0.215
Expression system: Escherichia coli BL21(DE3)