PDBe 2i6s

X-ray diffraction
2.7Å resolution

Complement component C2a

Released:

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C2a fragment Chain: A
Molecule details ›
Chain: A
Length: 517 amino acids
Theoretical weight: 58.46 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
  • Canonical: P06681 (Residues: 242-752; Coverage: 70%)
  • Best match: P06681-2 (Residues: 115-538)
Gene name: C2
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 51.16Å b: 75.08Å c: 71.56Å
α: 90° β: 110.32° γ: 90°
R-values:
R R work R free
0.216 0.212 0.287
Expression system: Mesocricetus auratus