Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Serine proteases, trypsin domain
- Peptidase S1A, chymotrypsin family
- von Willebrand factor, type A
- Peptidase S1, PA clan, chymotrypsin-like fold
- von Willebrand factor A-like domain superfamily
- Serine proteases, trypsin family, serine active site
- Serine proteases, trypsin family, histidine active site
- Peptidase S1, PA clan
1 more domain
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Complement C2a fragment (preferred)
PDBe Complex ID:
PDB-CPX-139130 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Complement C2a fragment
Molecule details ›
Chain: A
Length: 517 amino acids
Theoretical weight: 58.46 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
Sequence domains:
Structure domains:
Length: 517 amino acids
Theoretical weight: 58.46 KDa
Source organism: Homo sapiens
Expression system: Mesocricetus auratus
UniProt:
- Canonical:
P06681 (Residues: 242-752; Coverage: 70%)
Sequence domains:
Structure domains:
Ligands and Environments
1 bound ligand:
No modified residues
Experiments and Validation Details
X-ray source:
ESRF BEAMLINE ID14-2
Spacegroup:
P21
Expression system: Mesocricetus auratus
