2i5d

X-ray diffraction
1.63Å resolution

Crystal Structure of Human Inosine Triphosphate Pyrophosphatase

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 62 1076-81 (2006)
PMID: 17077483

Function and Biology Details

Reaction catalysed:
A nucleoside triphosphate + H(2)O = a nucleotide + diphosphate
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine triphosphate pyrophosphatase Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 21.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BY32 (Residues: 1-194; Coverage: 100%)
Gene names: C20orf37, ITPA, My049, OK/SW-cl.9
Sequence domains: Ham1 family
Structure domains: Maf protein

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 31.126Å b: 104.99Å c: 49.888Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.24
Expression system: Escherichia coli