› 2i3v

X-ray diffraction
2.4Å resolution

Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant

Released:
DOI: 10.2210/pdb2i3v/pdb
PDB entry 2i3v coloured by chain, front view.
PDB entry 2i3v coloured by chain, side view.
PDB entry 2i3v coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.
Armstrong N, Jasti J, Beich-Frandsen M, Gouaux E
Cell 127 85-97 (2006)
PMID: 17018279

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 259 amino acids
Theoretical weight: 29 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 413-620, 655-794; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand ZN 7 x ZN
Ligand GLU 4 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 63.191Å b: 106.291Å c: 192.817Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.281
Expression system: Escherichia coli

Quick links

Citations

20 review citations

The sequence of events that underlie quantal transmission at central glutamatergic synapses.
Lisman et al. (2007)
19 more

7 mentions without citation

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
6 more