2i0i

X-ray diffraction
2.8Å resolution

X-ray crystal structure of Sap97 PDZ3 bound to the C-terminal peptide of HPV18 E6

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Disks large homolog 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 85 amino acids
Theoretical weight: 8.78 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62696 (Residues: 459-543; Coverage: 9%)
Gene names: Dlg1, Dlgh1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Protein E6 Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 7 amino acids
Theoretical weight: 947 Da
Source organism: Human papillomavirus type 18
Expression system: Not provided
UniProt:
  • Canonical: P06463 (Residues: 152-158; Coverage: 4%)
Gene name: E6

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 94.167Å b: 61.919Å c: 57.142Å
α: 90° β: 123.33° γ: 90°
R-values:
R R work R free
0.223 0.223 0.289
Expression systems:
  • Escherichia coli
  • Not provided