2he4

X-ray diffraction
1.45Å resolution

The crystal structure of the second PDZ domain of human NHERF-2 (SLC9A3R2) interacting with a mode 1 PDZ binding motif

Released:

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 9.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15599 (Residues: 147-230; Coverage: 25%)
Gene names: NHERF2, SLC9A3R2
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 49.803Å b: 37.677Å c: 40.34Å
α: 90° β: 97.7° γ: 90°
R-values:
R R work R free
0.132 0.13 0.18
Expression system: Escherichia coli