Solution NMR

Solution structure of the eTAFH domain from the human leukemia-associated fusion protein AML1-ETO


Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Protein CBFA2T1 Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q06455 (Residues: 120-222; Coverage: 17%)
Gene names: AML1T1, CBFA2T1, CDR, ETO, MTG8, RUNX1T1, ZMYND2
Sequence domains: NHR1 homology to TAF
Structure domains: Four Helix Bundle (Hemerythrin (Met), subunit A)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: torsion angle dynamics
Chemical shifts: BMR7147  
Expression system: Escherichia coli