2gyp

X-ray diffraction
1.4Å resolution

Diabetes mellitus due to a frustrated Schellman motif in HNF-1a

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte nuclear factor 1-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 33 amino acids
Theoretical weight: 3.57 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20823 (Residues: 2-32; Coverage: 5%)
Gene names: HNF1A, TCF1

Ligands and Environments

No bound ligands
2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21212
Unit cell:
a: 29.18Å b: 42.95Å c: 42.37Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.228 0.288
Expression system: Not provided