› 2gw6

Solution NMR

NMR structure of the human tRNA endonuclease SEN15 subunit

Released:
DOI: 10.2210/pdb2gw6/pdb
PDB entry 2gw6 coloured by chain, ensemble of 20 models, front view.
PDB entry 2gw6 coloured by chain, ensemble of 20 models, side view.
PDB entry 2gw6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure determined for a subunit of human tRNA splicing endonuclease (Sen15) reveals a novel dimeric fold.
Song J, Markley JL
J Mol Biol 366 155-64 (2007)
PMID: 17166513

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186747 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
tRNA-splicing endonuclease subunit Sen15 Chains: A, B
Molecule details ›
Chains: A, B
Length: 123 amino acids
Theoretical weight: 13.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WW01 (Residues: 36-157; Coverage: 71%)
Gene names: C1orf19, SEN15, TSEN15
Sequence domains: Sen15 protein
Structure domains: Trna Endonuclease; Chain: A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics,simulated annealing,distance geometry
Expression system: Escherichia coli

Quick links

Citations

1 review citation

tRNA gene diversity in the three domains of life.
Fujishima et al. (2014)
8 other articles

7 mentions without citation

Recent Insights Into the Structure, Function, and Evolution of the RNA-Splicing Endonucleases.
Hirata A. (2019)
6 more