2g5b

X-ray diffraction
2.3Å resolution

Crystal Structure of the anti-Bax monoclonal antibody 6A7 and a Bax peptide.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
6A7 Fab Light Chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 217 amino acids
Theoretical weight: 24.09 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
6A7 Fab Heavy Chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 222 amino acids
Theoretical weight: 23.93 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
Apoptosis regulator BAX Chains: I, J, K, L
Molecule details ›
Chains: I, J, K, L
Length: 7 amino acids
Theoretical weight: 761 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q07812 (Residues: 13-19; Coverage: 4%)
Gene names: BAX, BCL2L4

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P21212
Unit cell:
a: 166.528Å b: 183.897Å c: 67.081Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.234 0.275
Expression systems:
  • Mus musculus
  • Not provided