X-ray diffraction
2.44Å resolution

orally active thrombin inhibitors

Source organisms:
Primary publication:
Orally active thrombin inhibitors. Part 1: optimization of the P1-moiety.
Bioorg. Med. Chem. Lett. 16 2641-7 (2006)
PMID: 16517159

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
Non-polymer only trimer (preferred)
Non-polymer only hexamer
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Decapeptide Hirudin Analogue Chain: D
Molecule details ›
Chain: D
Length: 11 amino acids
Theoretical weight: 1.51 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided

Ligands and Environments

1 bound ligand:

3 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 71.24Å b: 72.39Å c: 73.06Å
α: 90° β: 101.01° γ: 90°
R R work R free
0.185 0.185 0.242
Expression system: Not provided