PDBe 2f8y

X-ray diffraction
1.55Å resolution

Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution.


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Notch 1 intracellular domain Chains: A, B
Molecule details ›
Chains: A, B
Length: 223 amino acids
Theoretical weight: 24.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P46531 (Residues: 1905-2126; Coverage: 9%)
Gene names: NOTCH1, TAN1
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P65
Unit cell:
a: 97.933Å b: 97.933Å c: 109.068Å
α: 90° β: 90° γ: 120°
R R work R free
0.152 0.15 0.187
Expression system: Escherichia coli