X-ray diffraction
1.85Å resolution

The crystal structure of Bovine Lens Leucine Aminopeptidase in complex with zofenoprilat


Function and Biology Details

Reactions catalysed:
Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
Release of N-terminal proline from a peptide.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cytosol aminopeptidase Chain: A
Molecule details ›
Chain: A
Length: 486 amino acids
Theoretical weight: 52.87 KDa
Source organism: Bos taurus
  • Canonical: P00727 (Residues: 33-518; Coverage: 94%)
Gene name: LAP3
Sequence domains: Cytosol aminopeptidase family, catalytic domain
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELETTRA BEAMLINE 5.2R
Spacegroup: P6322
Unit cell:
a: 128.94Å b: 128.94Å c: 119.79Å
α: 90° β: 90° γ: 120°
R R work R free
0.156 0.156 0.177