PDBe 2ew5

X-ray diffraction
2.2Å resolution

Structure of Helicobacter Pylori peptide deformylase in complex with inhibitor


Function and Biology Details

Reaction catalysed:
Formyl-L-methionyl peptide + H(2)O = formate + methionyl peptide
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Peptide deformylase Chain: A
Molecule details ›
Chain: A
Length: 181 amino acids
Theoretical weight: 21.01 KDa
Source organism: Helicobacter pylori
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q672W7 (Residues: 2-174; Coverage: 99%)
Gene names: HPPMSS1_c00889, def
Sequence domains: Polypeptide deformylase
Structure domains: Peptide deformylase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 42.117Å b: 52.97Å c: 92.259Å
α: 90° β: 90° γ: 90°
R R work R free
0.213 0.201 0.254
Expression system: Escherichia coli BL21(DE3)