X-ray diffraction
1.9Å resolution

Crystal structure of the Keap1 protein in complexed with the N-terminal region of the Nrf2 transcription factor


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kelch-like ECH-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 318 amino acids
Theoretical weight: 35.01 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: Q9Z2X8 (Residues: 308-624; Coverage: 51%)
Gene names: Inrf2, Keap1, Kiaa0132
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller
Nuclear factor erythroid 2-related factor 2 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.8 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: Q60795 (Residues: 22-36; Coverage: 3%)
Gene names: Nfe2l2, Nrf2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P61
Unit cell:
a: 103.131Å b: 103.131Å c: 56.141Å
α: 90° β: 90° γ: 120°
R R work R free
0.174 0.172 0.211
Expression systems:
  • Escherichia coli
  • Not provided