PDBe 2dh4

X-ray diffraction
1.98Å resolution

Geranylgeranyl pyrophosphate synthase

Released:

Function and Biology Details

Reactions catalysed:
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Geranylgeranyl pyrophosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 340 amino acids
Theoretical weight: 39.3 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q12051 (Residues: 1-335; Coverage: 100%)
Gene names: BTS1, YPL069C
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL12B2, NSRRC BEAMLINE BL17B2
Spacegroup: P212121
Unit cell:
a: 48.747Å b: 116.331Å c: 129.768Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.243
Expression system: Escherichia coli BL21(DE3)