Solution NMR

Solution structure of RSGI RUH-049, a UBA domain from mouse cDNA

Source organism: Mus musculus
Entry authors: Hamada T, Hirota H, Lin Y-J, Guntert P, Kurosaki C, Izumi K, Yoshida M, Koshiba S, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
E3 ubiquitin-protein ligase CBL Chains: A, B
Molecule details ›
Chains: A, B
Length: 53 amino acids
Theoretical weight: 5.68 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: P22682 (Residues: 863-902; Coverage: 4%)
Gene name: Cbl
Sequence domains: UBA/TS-N domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided