› 2d39

X-ray diffraction
1.9Å resolution

Trivalent Recognition Unit of Innate Immunity System; Crystal Structure of human M-ficolin Fibrinogen-like Domain

Released:
DOI: 10.2210/pdb2d39/pdb
PDB entry 2d39 coloured by chain, front view.
PDB entry 2d39 coloured by chain, side view.
PDB entry 2d39 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain.
Tanio M, Kondo S, Sugio S, Kohno T
J Biol Chem 282 3889-95 (2007)
PMID: 17148457

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ficolin-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 237 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O00602 (Residues: 115-326; Coverage: 71%)
Gene names: FCN1, FCNM
Sequence domains: Fibrinogen beta and gamma chains, C-terminal globular domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL24XU
Spacegroup: P21
Unit cell:
a: 55.16Å b: 117.45Å c: 55.19Å
α: 90° β: 99.88° γ: 90°
R-values:
R R work R free
0.209 0.209 0.24
Expression system: Komagataella pastoris

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Citations

14 review citations

Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins.
Thiel S. (2007)
13 more

6 mentions without citation

Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens' Infectivity?
Hardy et al. (2023)
5 more