› 2ch0

Solution NMR

Solution structure of the human MAN1 C-terminal domain (residues 655- 775)

Released:
DOI: 10.2210/pdb2ch0/pdb
PDB entry 2ch0 coloured by chain, ensemble of 20 models, front view.
PDB entry 2ch0 coloured by chain, ensemble of 20 models, side view.
PDB entry 2ch0 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The carboxyl-terminal nucleoplasmic region of MAN1 exhibits a DNA binding winged helix domain.
Caputo S, Couprie J, Duband-Goulet I, Kondé E, Lin F, Braud S, Gondry M, Gilquin B, Worman HJ, Zinn-Justin S
J Biol Chem 281 18208-15 (2006)
PMID: 16648637

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195166 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inner nuclear membrane protein Man1 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y2U8 (Residues: 653-780; Coverage: 14%)
Gene names: LEMD3, MAN1
Sequence domains: Man1-Src1p-C-terminal domain
Structure domains: MAN1, winged-helix domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: DISTANCE GEOMETRY, SIMULATED ANNEALING
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

17 review citations

"Laminopathies": a wide spectrum of human diseases.
Worman et al. (2007)
16 more

3 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
2 more