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X-ray diffraction
1.9Å resolution

Crystal structure of Mycobacterium tuberculosis adenylate kinase complexed with two molecules of ADP and Mg

Released:

Function and Biology Details

Reaction catalysed:
ATP + AMP = 2 ADP
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase Chain: A
Molecule details ›
Chain: A
Length: 201 amino acids
Theoretical weight: 22.32 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P9WKF5 (Residues: 1-181; Coverage: 100%)
Gene names: MTV041.07, Rv0733, adk
Sequence domains: Adenylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 36.544Å b: 64.91Å c: 39.773Å
α: 90° β: 110.12° γ: 90°
R-values:
R R work R free
0.172 0.169 0.214
Expression system: Escherichia coli BL21(DE3)