2bwj

X-ray diffraction
2.3Å resolution

Structure of adenylate kinase 5

Released:
Source organism: Homo sapiens
Entry authors: Bunkoczi G, Filippakopoulos P, Fedorov O, Jansson A, Longman E, Ugochukwu E, Knapp S, von Delft F, Arrowsmith C, Edwards A, Sundstrom M, Weigelt J

Function and Biology Details

Reactions catalysed:
ATP + nucleoside diphosphate = ADP + nucleoside triphosphate
ATP + AMP = 2 ADP
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenylate kinase isoenzyme 5 Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 199 amino acids
Theoretical weight: 22.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6K8 (Residues: 365-562; Coverage: 35%)
Gene name: AK5
Sequence domains: Adenylate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P61
Unit cell:
a: 180.375Å b: 180.375Å c: 121.701Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.172 0.213
Expression system: Escherichia coli BL21(DE3)