PDBe 2bbu

Solution NMR

solution structure of mouse socs3 in complex with a phosphopeptide from the gp130 receptor


Function and Biology Details

Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Suppressor of cytokine signaling 3 Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 17.96 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
  • Canonical: O35718 (Residues: 22-185; Coverage: 73%)
Gene names: Cis3, Cish3, Socs3
Sequence domains: SH2 domain
Structure domains: SH2 domain
Interleukin-6 receptor subunit beta Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.61 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: Q00560 (Residues: 750-764; Coverage: 2%)
Gene name: Il6st

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 70%
Refinement method: simulated annealing distance geometry torsion angle dynamics
Chemical shifts: BMR6580  
Expression systems:
  • Escherichia coli BL21
  • Not provided