X-ray diffraction
2.41Å resolution

Crystal structure of the MDC1 brct repeat in complex with the histone tail of gamma-H2AX


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
Non-polymer only dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mediator of DNA damage checkpoint protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 207 amino acids
Theoretical weight: 22.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: Q14676 (Residues: 1883-2089; Coverage: 10%)
Gene names: KIAA0170, MDC1, NFBD1
Structure domains: BRCT domain
Histone H2AX Chains: C, D
Molecule details ›
Chains: C, D
Length: 10 amino acids
Theoretical weight: 1.24 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: P16104 (Residues: 134-143; Coverage: 7%)
Gene names: H2AFX, H2AX

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P212121
Unit cell:
a: 67.437Å b: 75.609Å c: 114.849Å
α: 90° β: 90° γ: 90°
R R work R free
0.194 0.191 0.248
Expression systems:
  • Escherichia coli BL21
  • Not provided