X-ray diffraction
2.5Å resolution

Crystal structure of the kinase domain of human 3'-phosphoadenosine 5'-phosphosulphate synthetase 2

Source organism: Homo sapiens
Entry authors: Rabeh WM, Nedyalkova L, Ismail S, Park H, Arrowsmith C, Edwards A, Sundstrom M, Weigelt J, Bochkarev A, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed:
ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate
ATP + sulfate = diphosphate + adenylyl sulfate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 198 amino acids
Theoretical weight: 21.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: O95340 (Residues: 21-218; Coverage: 32%)
Gene names: ATPSK2, PAPSS2
Sequence domains: Adenylylsulphate kinase
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 52.914Å b: 131.892Å c: 70.562Å
α: 90° β: 104.58° γ: 90°
R R work R free
0.215 0.212 0.278
Expression system: Escherichia coli BL21